Out of the box, Radical Red comes with some of the best QoL features out there, helping to keep the focus on the intelligently designed and often grueling battles, and not some of the more tedious aspects you may remember from your youth. With that spirit in mind, here's my challenge recommendation, designed to maximize what is great about Radical Red, and to help you enjoy every last Pokemon, Ability, and Move through Gen 9.
Called Radical Random: Mono, the challenge is to efficiently Defeat All Boss Trainers with a Randomized, Monotype Team of 6 Pokemon from your Pool. Target Runtime is a 10hr clear to Champion.
Lets get specific:
Start with a New Game+ Save of Radical Red 4.1. (If you don't have one, you should definitely play the game as intended first. My first clear on 3.1 took me over 80hrs, and I needed every minute of the training.)
When Asked: "Do you want to simply play Radical Red without any custom options?" Select NO
Difficulty Options: DEFAULT
Minimal Grinding Mode: YES
Species Randomizer: NORMAL SPECIES
Ability Randomizer: YES
Learnset Randomizer: YES
Hit DONE and lets get to implementing some built in QoL 'Cheats'.